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Genital inflammation reduces efficacy of tenofovir gel against HIV in women

The researchers performed a post hoc prospective analysis of 774 patients who participated in the Centre for the AIDS Program of Research In South Africa (CAPRISA) 004 study, a trial of topical tenofovir gel. McKinnon and colleagues measured concentrations of nine different proinflammatory cytokines from cervicovaginal lavages, and defined genital inflammation using a graduated cytokine store.

Published
28 February 2018
From
Healio
Do HIV-Preventing Microbicides Have a Future in the Age of PrEP?

Courting controversy, the NIH considers a shift away from the development of new vaginal or rectal-based HIV prevention products.

Published
11 December 2017
From
Poz
Vital Microbicides May Soon Be Out of Reach

Whether, when, and how microbicide development proceeds depends on the U.S government, and the federal Division of AIDS has suggested this development may no longer be a priority. It's wrong.

Published
10 November 2017
From
Rewire
DAIDS Boss Muses on the Future of HIV Prevention Research

Below are some of Dr. Dieffenbach’s rather intentionally provocative ideas about specific HIV prevention research candidates—challenges and promises, and the questions they may raise for the next clinical trial research network structure.

Published
20 October 2017
From
AVAC
Population Council Advances Non-Antiretroviral Multipurpose Prevention Technology For HIV and STI Prevention to Clinical Trial

First in-human clinical trial of griffithsin, a naturally occurring anti-HIV protein, which limits risk of cross-resistance to antiretroviral (ARV) products.

Published
16 October 2017
From
Population Council
Free Your (and Carl's) Mind: An Open Letter to Anthony Fauci About HIV Prevention Research Priorities

Please Tony, help Carl free his mind to consider microbicides with the same passion and intensity and commitment he has for vaccines and long-acting formulations. He has heard us say these things many times over this year, but he has yet to really listen, I am sorry to say. He seems to listen only when it fits in with his vision.

Published
11 October 2017
From
The Body Pro
Save Microbicide Research and Development

Ongoing funding and support for vaginal and rectal microbicide research and development is in serious danger! Let NIAID know you want the research to continue.

Published
18 September 2017
From
IRMA
Dapivirine vaginal ring safe, acceptable for HIV prevention in teens

A monthly vaginal ring containing the antiretroviral dapivirine has demonstrated efficacy in girls younger than 18 years, according to phase 2a study results presented at the IAS Conference on HIV Science.

Published
27 July 2017
From
Healio
Rectal products for PrEP: Are they an option?

At the IAS 2017 conference this week, Ian McGowan, MD, PhD, FRCP, from University of Pittsburgh, discussed the need for (and challenges associated with) topical HIV prevention products, and a separate team of researchers presented promising findings from a very early study of a rectal HIV-prevention douche.

Published
27 July 2017
From
BETA blog
IPM receives award of up to $25 million From USAID to advance HIV prevention products for women

The award will expedite the potential licensure and market introduction of a new HIV prevention microbicide product for women, who continue to be disproportionately affected by the global HIV/AIDS epidemic.

Published
26 July 2017
From
Eurekalert Medicine & Health

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Community Consensus Statement on Access to HIV Treatment and its Use for Prevention

Together, we can make it happen

We can end HIV soon if people have equal access to HIV drugs as treatment and as PrEP, and have free choice over whether to take them.

Launched today, the Community Consensus Statement is a basic set of principles aimed at making sure that happens.

The Community Consensus Statement is a joint initiative of AVAC, EATG, MSMGF, GNP+, HIV i-Base, the International HIV/AIDS Alliance, ITPC and NAM/aidsmap
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